Liquid-liquid extractions have long been performed manually and are used to extract and concentrate analytes from aqueous matrices. Inclusion of liquid-liquid extraction in many official methods attests to the wide acceptance of the technique. Following solvent extraction it is also common to include an evaporation and reconstitution step to improve detection limits or exchange solvents for compatibility with subsequent chromatographic separations.
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Automating Liquid-Liquid Extractions Using an X-Y-Z Coordinate Autosampler for LC-MS/MS Analyses